The main pharmaco-therapeutic effects: membrane, antihistamine effect, sensitization inhibits eosinophil recombinant human cytokines and their slat in the airways, prevents the development of symptoms hiperreaktyvnosti respiratory tract caused by platelet activating factor, or the action of allergens, prevents the development of bronchospasm (no bronhorozshyryuyuchu action); razvyvayetsya clinical effect after 6-8 weeks. Of any of these cases were not related bleeding episodes or reduced hemoglobin. Pharmacotherapeutic group: R03DX03 - means acting on the respiratory system. An important aspect of anti-allergic effects membrane stabilizers of smooth cells is increasing sensitivity to blockers of catecholamines. Indications: slat and g. Stabilizers membranes of smooth cells more effective in children over 4 years than in adults. Zafirlukast is used also for prophylactic purposes, can prevent the development of asthma. Contraindications to the use of drugs: hypersensitivity to the drug, children under 12 years. Montelukast therapy joins patients with mild asthma and moderate severity of their inadequate treatment of inhaled corticosteroids and 2-adrenoceptor short action.? Also, to prevent allergen-induced bronchospasm. NAM in the complex treatment of asthma, seasonal and year-round allergic rhinitis and other allergic manifestations of the respiratory system and upper respiratory tract, the respiratory manifestations of measles, influenza; symptomatic treatment slat whooping cough. In addition, drugs block the chloride channels and prevent thus depolarization of parasympathetic endings in bronchi. (100 mg) 4 g / day (40 mg / kg / day) for adults and children; intranasal - 1 aerosol dose in each nasal passage 4.3 g / day; dosed aerosol inhalation for 1-2 doses of 4.6 (up to 8) g / day for adults and children over 5 years in the early treatment of asthma, in severe cases of asthma in 2 doses of 8.6 g / day, with clinical polibshenni - 1 dose of 4 g / day; to prevent asthma physical zusylyya immediately before physical work can be conducted additional use of therapeutic agent. Some drugs of this group (Ketotifen, etc.). Prostohlandyny and their synthetic derivatives. The main indication slat the use of stabilizers membranes of smooth cells (kromohlitsiyeva acid and its analogues, ketotifen) is Prevention of bronchial obstruction that develops in asthma, thus ineffective to relieve worsening asthma. Other drugs for systemic use in Obstructive diseases of the respiratory system. If inhalation powder drugs cause bronchospasm, recommended prophylactically (a few 2-agonist.?min) to inhalation Preventive effect razvyvayetsya gradually, during the 12.2 weeks. Contraindications to the use of drugs: hypersensitivity to the drug.Method of production of drugs: Table., Coated tablets, each 80 mg, syrup 150 ml (200 mg/100 ml) vial. Dosage and Administration: Table., Coated tablets recommended for oral use with adults and children 14 Resin Uptake old; usual recommended daily therapeutic dose for treatment of XP. The main pharmaco-therapeutic effects: anti-inflammatory action; tool is an antagonist of leukotrienes LTS4, LTD4, LTE4, a high Outpatient Department CysLT1 and selectivity to receptors, blocking the receptor and prevents CysLT1 stimulation of leukotrienes cells targets, such as bronchial slat muscles and secretory glands inhibits Digital Subtraction Angiography early and late phases bronhokonstryktsiyi caused which the antigens slat . Side effects of drugs and complications of the use of drugs: indigestion, nausea, stomach pain, drowsiness, in rare cases - Mild sinus tachycardia, which decreases when lowering the dose, erythema, pigmentary fixed erythema, rash, urticaria, angioneurotic edema. Method of production of drugs: powder for Mr injection of 75 mg, 150 mg in Flac. Stabilizers smooth cell membrane is used to prevent asthma symptoms caused by exercise, conducted by inhalation 30 min before the slat load. In the respiratory tract will block the action leukotrienes, including preventing the formation of slat secretion in the bronchi, swelling of Immediately membranes, bronchi and weakening hyperreactance bronchospasm. inflammation of upper respiratory tract and respiratory tract (otitis, sinusitis, rhinitis, rynofarynhit, tracheitis, rynotraheobronhit, bronchitis), COPD with or without HR. At the beginning of treatment drugs commonly used 4.3 g / day in achieving optimal therapeutic effect can switch to a supportive dose selected individually. This receptor antagonists leykotriyenovyh ineffective for removal of BA seizures, shall not apply to the exacerbation of asthma.
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