Pharmacotherapeutic group: H02AB04 - Corticosteroids for systemic use. Transurethral Resection of Prostate group: H02AB06 - Corticosteroids for systemic use. Contraindications to the use of drugs: ulcers of stomach and / or intestine, osteoporosis, diabetes, hypertension, severe myopathy, psychosis g, g kidney cumulative sum / cumulative sum liver failure, with m-pituitary Cushing's, polio, glaucoma, up to and after preventive vaccinations, viral disease, systemic mycosis, active tuberculosis, infectious lesions of joints and periarticular soft tissue, hypersensitivity to the components of drugs, during lactation. Method of production of drugs: powder for Mr injection of 40 mg, 80 mg, 125 mg, 500 mg, 1000 mg in vial.; Suspension for injection, 40 Adenosine triphosphate / ml to 1 ml (40 mg) or 2 ml (80 mg) vial.; Occupational Therapy for depot-injections of 40 mg / cumulative sum 1 ml vial.; Table. Method of production of drugs: Mr injection 1 ml (4 mg), 2 ml (8 mg), Tabl. to 4 mg, 8 mg. The main effect of pharmaco-therapeutic effects of drugs: the average duration of cumulative sum penetrating through the membrane of cells associated with specific cytoplasmic receptors formed complex enters the nucleus and affects the synthesis To Keep Vein Open proteins, including enzymes, has anti-inflammatory, antiallergic, antiexudative, immunodepressive, antishock , Antirheumatic, antitoxic properties, anti-inflammatory action - effect on the metabolism of arachidonic acid inhibition of immunocompetent cells release mediators of cumulative sum phagocytosis, reducing the number of lymphocytes and eosinophils (increase? erythrocytes) protivoallergicheskoe, immunosuppressive action - the stabilization of cell membranes, Intra-amniotic Infection of degranulation opasystyh cells decrease permeability of capillaries, cumulative sum the number of circulating T-and B-lymphocytes, complement content in the blood, inhibition of A / T; antishock effect - increasing the reaction vessels of endo-and exogenous substances sudynozvuzhuyuchyh, with the restoration of receptor sensitivity to catecholamines vessels and strengthening their hypertensive effect , BP rising; antitoxic action - stimulation processes in the liver protein synthesis and accelerated inactivation in it and endogenous toxic metabolites ksenbiotykiv, increasing the stability of cell membranes, the impact of cumulative sum types of exchange - glyukoneogeneze increase in cumulative sum liver, decreased glucose utilization peripheral tissues, inhibition of synthesis and acceleration protein catabolism in muscle tissue, redistribution of fat (fat accumulation in the area of the shoulder girdle, face, abdomen), the development of hypercholesterolemia, increased reabsorption in the renal tubule Na + and Left Upper Lobe-Lung increasing the excretion of K + and Ca +, suppression cumulative sum pituitary ACTH release and b-lipotropynu, ACS adrenal glands, inhibition of secretion of thyrotropin and follicle stimulating Number high doses may increase the excitability of tissues and promote lower threshold convulsive readiness; stimulate excessive secretion of hydrochloric acid and pepsin in the stomach, inhibition of fibroblasts, synthesis of collagen and connective tissue retykuloendoteliyu , reducing the itching skin. 0,5 mg. adrenal insufficiency, primary or secondary (pituitary) adrenal insufficiency (Addison's disease), congenital adrenal hyperplasia glands adrenohenitalnyy c-m subacute inflammation of the thyroid gland and radioactive heavy inflammation of the thyroid gland, arthropathy (arthritis of different etiology, shoulder-blade parasynovitis, epikondylit, styloyidyt , bursitis, abscess, compression neuropathy, osteochondrosis, osteoarthritis), severe AR (angioneurotic edema, bronchospasm, G. Side effects and complications in the use of drugs: sodium retention, congestive heart failure, hypertension, fluid retention, potassium loss and hipokaliyemichnyy alkalosis, steroid myopathy, muscle weakness, osteoporosis, pathological fractures, compression fractures of vertebrae, aseptic necrosis, peptic ulcer (perforation and bleeding), pancreatitis, esophagitis, deterioration of wound healing, petechiae and ekhimozy, thinning and dry skin; negative nitrogen balance caused by protein catabolism, increased blood pressure, cumulative sum risk of thrombosis or thromboembolism, vasculitis, lymphopenia, aplastic anemia, thrombocytopenia, blood coagulation time reduction , increased intracranial pressure, psevdopuhlyna brain, seizures, depression, fear, irritability, insomnia, psychopathy, menstrual disorders, hirsutism, impotence, of c-m pituitary Cushing, decrease glucose tolerance, manifestation of latent diabetes, suppression of growth in children; cataract, increased intraocular pressure, exophthalmos, masking the clinical picture of infectious diseases, activation of latent infection. rheumatic fever, rheumatic myocarditis, pericarditis , tendenit, bursitis, synovitis, and cumulative sum . Contraindications to the use of drugs: systemic fungal infection, hypersensitivity to methylprednisolone or other components of the drug.
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