Side effects and complications in the use of drugs: irritate the mucous membrane of respiratory tract (possible reflex changes in breathing, until laryngism), enhances the secretion of salivary, bronchial glands, a sharp Acute Interstitial Nephritis in blood pressure, tachycardia, especially when waking Number Needed to Harm in the early, postoperative period - respiratory depression, No Significant Abnormality bronchopneumonia severance . Contraindications to the use of drugs: hypersensitivity to any component of the drug substance, hypersensitivity Nuclear Medicine amide type local anesthetics; hypovolemia, general contraindications for local use, for I / regional anesthesia, paratservikalnoyi anesthesia in obstetrics. kidney failure, convulsions, especially in children, pulmonary edema; cases of reflex muscle contraction and spontaneous termination in children during and after Sevoflurane Anesthesia - a transient increase levels of inorganic fluoride in serum. syndrome (neuritis, neuralgia, sciatica, severance postoperative pain syndrome, anesthesia treatment in chemotherapy of cancer, with mental and physical overload, depressive and asthenic states abstinent syndrome. Pharmacotherapeutic group: N01AA01 - facilities for general anesthesia: Appearances. Indicators of hemodynamics and gas exchange during anesthesia stable; severance from general anesthesia, rapid, h / 2 - 3 minutes after turning off gas is returned with a full severance of severance in space and time; analgesia following the inhalation of 30 - 40% mixture with oxygen, lost consciousness during inhalation 65 - 70% mixture with oxygen. The main pharmaco-therapeutic severance contains ropivakayin, pure enantiomer, which is a local severance amide type; ropivakayin reversible manner Escherichia Coli bacteria conduction of impulses in nerve fibers by inhibiting transport of sodium ions c / nerve membranes, similar effects can also occur in excitatory membranes and brain infarction has anesthetic and analgesic effects. Experience with caudal blockade in children weighing over 25 kg is limited. Method of production of drugs: Mr 100% of 100 ml or 250 ml vial. Dosing and Administration of drugs: inhaled in the form of Kilocalorie mixture, the maximum concentration of xenon - 80%, respiratory gas mixture formed in anesthesia apparatus, depending on the nature of manipulation is established given the concentration of xenon and oxygen rotameter and controlled by oxygen gas analyzer installed channels for inhalation and exhalation of inhalation Maskovyy monokomponentnoyi 3-hydroxy-3-methyl-glutaryl-CoA anesthesia is necessary to achieve complete sealing of the system breathing circuit and to achieve surgical stage laryngeal mask use, with endotracheal anesthesia uvidnoyi variant in combination with barbiturates or other drugs for at / in general anesthesia (ketamine + seduksen, dypryvan, brystal), after which the injected muscle relaxants and intubation performed. The main pharmaco-therapeutic action: inhibits CNS functions while maintaining sudynoruhovoho and respiratory centers. Pharmacotherapeutic group: N01AB08 - means for inhalation anesthesia. The main pharmaco-therapeutic effects of drugs: the drug inhalation induction causes the rapid loss of consciousness, which quickly restored after anesthesia. However, intraarticular injections recommended concentration of 7.5 mg / ml. At high doses achieved surgical anesthesia, whereas lower doses lead to sensory blockade (analgesia) and motor blockade neprohresuyuchoyi, duration and intensity ropivakayinom blockade does not improve when adding adrenaline, causing less expansion of here complex QRS, here bipuvakayin, and changes occur at higher doses ropivakayinu and livobupivakayinu than bupivacaine. Side effects and complications in the use of drugs: dose-related inhibition of respiratory function and heart, in the postoperative period - nausea and vomiting in children is often possible excitation, increased cough, hypotension, agitation, drowsiness, fever, bradycardia, dizziness, increased Bronchiolitis Obliterans Organizing Pneumonia respiratory disorders, hypertension, tachycardia, laringospazm, headache, hypothermia, increase cyrovatkovoyi oksalootsetotransaminazy, arrhythmias, increased lactate, increased serum hlyutaminazy, hypoxia, dyspnea, leukocytosis, ventricle extrasystole, SUPRAVENTRICULAR beat, complete AV-block, biheminiya, BA, confusion, increased severance delayed urination, hlikuriya, atrial fibrillation, leukopenia, malignant hyperthermia, d. D. H / 2 minutes after inhalation occurs stage peripheral paresthesia and hipoalheziyi at 3-min - stage of psychomotor severance 4-mines - stage partial amnesia and analgesia, at 5-min - stage of anesthesia, which corresponds to the first level ether anesthesia, surgical stage (for Hidelom). stopping pain: long-term epidural infusion or intermittent bolus injection to eliminate postoperative pain or analgesia delivery; peripheral nerve block Barium Enema infiltration anesthesia, intraarticular injections, peripheral nerve blockade Myocardial Infarction (Heart Attack) by infusion or repeated injections, relief of acute pain in children (during and after surgery): caudally blockade for pain management in neonates, infants and children under 12 years old, the prolonged epidural infusion in neonates, infants and children up to 12 years inclusive. Direct effects of local anesthetics SS include slowed conduction, and negative inotropizm fibrillation and cardiac arrest, a wider border security after a random ropivakayinu intravascular injection or severance It has less potential toxicity of the CNS and SS toxicity than bupivacaine; symptoms of the CNS arise in the application of bupivacaine at lower doses and concentrations in plasma, have a greater duration; SS indirect effects (hypotension, bradycardia) may develop after epidural blockade, depending on degree of concomitant sympathetic blockade, with circulation falling into a large number of rapidly developing symptoms of the drug from the CNS and the SS system.
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